The TAB1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TAB1. This antibody recognizes Human antigen. The TAB1 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1